[11 XU X, CHEN P, WANG J, et al. Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission[]. SCIENCE CHINA-LIFE SCIENCES. 2020. [12]CERAOLO C, GIORGI F M. Genomic variance of the 2019-nCoV coronavirus(Z]. Biorxiv, 2020 htts/ doi. org/l0.1101/2020.0202931162 [13 BENVENUTO D, GIOVANNETTI M, CICCOZZI A, et al. The 2019-new coronavirus epidemic Evidence for virus evolution[J]. J Med Virol, 2020 114 LI F, LI WH, FARZAN M, et al. Structure of SARs coronavirus spike receptor-binding domain omplexed with receptor[J]. SCIENCE, 2005, 309(5742): 1864-1868 [15LU G, HU Y, WANG Q, et al. Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26J. NATURE, 2013, 500(7461): 227 [16] WAN Y, SHANG J, GRAHAMR, et al. Receptor recognition by novel coronavirus from wuhan An analysis based on decade-long structural studies of SARS].J Virol, 2020 [17 ZHOU P, YANG X, WANG X, et al. 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The digestive system is a potential route of 2019-nCoV infection: a bioinformatics analysis based on single-cell transcriptomes[z]. Biorxiv, 2020, htts/ doi.org/l0.110/2020.01.30927806 [23] ZHAO S, LIN Q, RAN J, et al. Preliminary estimation of the basic reproduction number of novel coronavirus(2019-nCov)in China, from 2019 to 2020: A data-driven analysis in the early phase of the outbreak[J]. Int J Infect Dis, 2020 24] BAUCH CT, LLOYD-SMITH JO, COFFEE MP, et al. Dynamically modeling SARS and other newly emerging respiratory illnesses: Past, present, and future[J]. Epidemiology, 2005 16(6):791-801 25]LIN Q, CHIU AP, ZHAO S, et al. Modeling the spread of Middle East respiratory syndrome coronavirus in Saudi Arabia[J]. Stat Methods Med Res, 2018, 27(7): 1968-1978 26] RAHMAN A, SARKAR A Risk factors for fatal Middle East respiratory syndrome coronavirus ifections in Saudi Arabia: Analysis of the WHO Line List, 2013-2018J]. Am J Public Health 2019,109(91288-1293 [27 HUNG IF, CHENG VC, WU AK, et al. Viral loads in clinical specimens and SARS manifestations[J]. Emerg Infect Dis, 2004, 10(9): 1550-1557 数字平台:htp/ xxb xjtu.edu.cn微信公众号:西安交通大学学报医学版西安交通大学学报（ 医学版 ） 数字平台：http://yxxb.xjtu.edu.cn 微信公众号：西安交通大学学报医学版 [11] XU X, CHEN P, WANG J, et al. Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission[J]. SCIENCE CHINA-LIFE SCIENCES, 2020. [12] CERAOLO C, GIORGI F M. Genomic variance of the 2019-nCoV coronavirus[Z]. Biorxiv, 2020, https://doi.org/10.1101/2020.02.02.931162. [13] BENVENUTO D, GIOVANNETTI M, CICCOZZI A, et al. The 2019-new coronavirus epidemic: Evidence for virus evolution[J]. J Med Virol, 2020. [14] LI F, LI WH, FARZAN M, et al. Structure of SARS coronavirus spike receptor-binding domain complexed with receptor[J]. SCIENCE, 2005,309(5742):1864-1868. [15] LU G, HU Y, WANG Q, et al. 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