Scales and levels of brain networks Basic structure of brain networks(node and connection can be defined at different scales Microscale: neurons and Mesoscale: connections Macroscale: anatomically their synaptic connections within and between distinct brain regions and (about 1010 neurons in the minicolumns(about 2x108 inter-regional pathways cortey ) inicolumn in the cortex about 100 regions in the Voxel based Brain network Analysis Basic elements can be derived from Medical Imaging echniques Scale Neurons Columns 10K-100K Sporns et al(2005)PLoS Comput BiolScales and levels of brain networks ◼ Basic structure of brain networks (node and connection) can be defined at different scales. Sporns et al (2005) PLoS Comput Biol Macroscale: anatomically distinct brain regions and inter-regional pathways (about 100 regions in the cortex). Columns Regions Mesoscale: connections within and between minicolumns (about 2×108 minicolumn in the cortex ). Neurons Microscale: neurons and their synaptic connections (about 1010 neurons in the cortex). Voxel based Brain network Analysis Basic elements can be derived from Medical Imaging Techniques Scale: 10K-100K