Mother nature's gifts to diseases of man 24 25 recent overview by Demain and the references therein 1231 together with the excellent review by Baltz et al.on the use of genetic constructs in developing further congeners of daptomycin (18)[24]and from a historical to current perspective,the excellent review by von Nussbaum and co-workers covering the older and modern literature from a medici- nal chemistry/lead discovery and optimization aspect should definitely be consulted [25]. 2.1.3 Antibacterials:current status Since 2000,six new NP-derived drugs have been launched:ertapenem (200l,Invanz,Merck)(19[26,27，telithromycin(2001,Ketek®，Sanofi 9Mother nature’s gifts to diseases of man 9 recent overview by Demain and the references therein [23], together with the excellent review by Baltz et al. on the use of genetic constructs in developing further congeners of daptomycin (18) [24] and from a historical to current perspective, the excellent review by von Nussbaum and co-workers covering the older and modern literature from a medici￾nal chemistry/lead discovery and optimization aspect should definitely be consulted [25]. 2.1.3 Antibacterials: current status Since 2000, six new NP-derived drugs have been launched: ertapenem (2001, Invanz®, Merck) (19) [26, 27], telithromycin (2001, Ketek®, Sanofi-