PEP From pyruvate Bicarbonate Pyruvate cytosolic PEP to PEP: two HO-C+ CH3-C Oxaloacetate alternative paths ATP NADH+H+ pyruvate cytosolic arboxylnse biotin malate ADP P NAD+ Malate Oxaloacetate Malate PEP NAD+ Oxaloacetate mitochondrial PEP CC-CH2*C-C NADH+H+ carboxykinase Oxaloacetate Oxaloacetate pyruvate carboxylase pyruvate CO rboxylase cO Guanosine 0-P-0-P-0-P-O Pyruvate TP Mitochondrion Cytosol →GDP PEP Pyruvate carboxykinase NADH +H+ 03 lactate dehydrogenase CH,=C-Coo NAD+ Phosphoenolpyruvate Lactate b)From pyruvate to PEP: two alternative paths