12.Which of the following statements is correct? A.Autophagy is a rare process that is always associated with disease. B.Autophagy is important in cellular defense against microorganisms. C.Autophagy is not involved in cellular differentiation. D.The autophagic vacuole fuses with a lysosome to form an autophagolysosome E.The autophagic vacuole is formed by mitochondria. Ans:D After a pha osome full ofproteolytic b organelle acrophages engul 90pagRaaC9mpicaei3gnorraeOaemror8am on of RBCs,B-cells,adipocytes,osteoclasts,and keratinocytes.This process is critical to cellular remodeling.The vacuole results from endocytosis at the plasma membrane,not the mitochrondria. -8- 8 - 12. Which of the following statements is correct? A. Autophagy is a rare process that is always associated with disease. B. Autophagy is important in cellular defense against microorganisms. C. Autophagy is not involved in cellular differentiation. D. The autophagic vacuole fuses with a lysosome to form an autophagolysosome. E. The autophagic vacuole is formed by mitochondria. Ans: D After a phagosome has been internalized into the cell, it fuses with a lysosome full of proteolytic enzymes that will degrade the contents of the vacuole. Autophagy is a physiologic process by which a cell digests its own unnecessary or dysfunctional organelles. Macrophages engulf bacteria via phagocytosis, not autophagy, in order to destroy invasive microorganisms. Autophagy has been implicated differentiation of RBCs, B-cells, adipocytes, osteoclasts, and keratinocytes. This process is critical to cellular remodeling. The vacuole results from endocytosis at the plasma membrane, not the mitochrondria