PREFACE "Experimental teaching material of medicinal chemistry"is composed according to the outline of medicinal chemistry.The purpose of this book is,through experiment,to comprehend elementary theory and knowledge of medicinal chemistry better,to grasp fundamental methods of synthesis and structural modification of drugs,to be familiar with how to design the experiment plan and how to select the experiment condition,to understand application of principle of hybridization and modern new technology and method in medicinal chemistry experiment,to standard and consolidate manipulative technology and relevant theory knowledge of organic chemistry experiment,to train students'style of integrating theory with practice,scientific attitude of seeking truth from fact and being rigorous and serious,ability of analyzing and solving actual problems,and good custom of scientific research. The characteristic of this book is adding much designing experiments to guiding experiments. It requires students to complete as independently as possible that consulting literatures,designing route and experimental manipulate.Through the training of designed experiments,whole process of scientific research is simulated.Students'consciousness of scientific research,spirit of bringing new ideas,ability of working independently and solving actual problems by theory and relevant elementary and professional knowledge of medicinal chemistry are trained.It can be the foundation of being engaged in medicine synthesis,studying new drugs and carrying out clinical medicinal chemistry. This book is the collective summary of teaching experience in department of medicinal chemistry.If there is any mistake in this book,please produce precious opinions during using it, so that we will corret and elevate when second printing or edition. School of Pharmacy Shanghai Jiaotong University 2008.11 PREFACE “Experimental teaching material of medicinal chemistry” is composed according to the outline of medicinal chemistry. The purpose of this book is, through experiment, to comprehend elementary theory and knowledge of medicinal chemistry better, to grasp fundamental methods of synthesis and structural modification of drugs, to be familiar with how to design the experiment plan and how to select the experiment condition, to understand application of principle of hybridization and modern new technology and method in medicinal chemistry experiment, to standard and consolidate manipulative technology and relevant theory knowledge of organic chemistry experiment, to train students’ style of integrating theory with practice, scientific attitude of seeking truth from fact and being rigorous and serious, ability of analyzing and solving actual problems, and good custom of scientific research. The characteristic of this book is adding much designing experiments to guiding experiments. It requires students to complete as independently as possible that consulting literatures, designing route and experimental manipulate. Through the training of designed experiments, whole process of scientific research is simulated. Students’ consciousness of scientific research, spirit of bringing new ideas, ability of working independently and solving actual problems by theory and relevant elementary and professional knowledge of medicinal chemistry are trained. It can be the foundation of being engaged in medicine synthesis, studying new drugs and carrying out clinical medicinal chemistry. This book is the collective summary of teaching experience in department of medicinal chemistry. If there is any mistake in this book, please produce precious opinions during using it, so that we will corret and elevate when second printing or edition. School of Pharmacy Shanghai Jiaotong University 2008.1