2 The mechanisms of nsaids NSAID inhibition of Pg production alleviates most of the pathologic effects associated with inflammation but it also interferes with the physiologic role of these molecules Consequently, long-term therapy with nonspecific NSAIDs is frequently limited by their adverse effects, particularly those caused by erosion of gastric mucosal protection - Gl bleeding➢ NSAID inhibition of PG production alleviates most of the pathologic effects associated with inflammation, but it also interferes with the physiologic role of these molecules ➢ Consequently, long-term therapy with nonspecific NSAIDs is frequently limited by their adverse effects, particularly those caused by erosion of gastric mucosal protection —— GI bleeding 2. The mechanisms of NSAIDs