COo ATP PP,+ P H3N-C-H S-Adenosylmethionine Methionine CHe *s-Adenosine CH domE PLP H3N--CH2-CH2-CH2-CH-CO0 Ornithine decarboxylase N→Co2 PLP ormithine cO2 H3N-CH2 " CH H3N-(CH2)4-NH3 Putrescine H propylaminotransferase - Adenosine →CH3-S- Adenosine CH3 Methylthioadenosine Decarboxylated adoMet H3N-(CH2)3-NH-(CH)4-NH3 Spermidine propylaminotransferase II →CH3-S- Adenosine Spermidine and spermine HgN-(CH2)3-NH-(CH2)4-NH-(CH2)3-NHs are derived from met perming and ornithineSpermidine and spermine are derived from Met and ornithine