transcription of genes required for r7 differentiation. In different cells in the same animal, ras can be activated by an activated growth factor receptor. This leads to transcription of genes required for cell division egl A GDP GDP GTP transcription of genes for R7 development transcription of genes for cell division How is it possible for the activation of Ras to lead to transcription of different sets of genes? ii)Given that these cells exist in the same animal, name one component in the pathway that could be mutated to give each of the following results(consider each situation independently). Describe how the mutant component differs from the wild-type component, and whether it is a loss-of-function or gain-of-function mutation You never see differentiation of rz cells You see uncontrolled cell proliferation Question 7 You are studying a common genetic condition. The mutant allele differs from the wild-tyrexg allele by a single base-pair(bp)substitution. This substitution eliminates a Nhel restriction si that is present in the wild-type allele. The mutant allele is not cut by Nhel. )a pedigree of a family exhibiting this condition is shown below: normal female affected male affected female Spring 2004 Final exam practiceSpring 2004 Final Exam Practice 10 transcription of genes required for R7 differentiation. In different cells in the same animal, Ras can be activated by an activated growth factor receptor. This leads to transcription of genes required for cell division. i) How is it possible for the activation of Ras to lead to transcription of different sets of genes? ii) Given that these cells exist in the same animal, name one component in the pathway that could be mutated to give each of the following results (consider each situation independently). Describe how the mutant component differs from the wild-type component, and whether it is a loss-of-function or gain-of-function mutation. • You never see differentiation of R7 cells. • You see uncontrolled cell proliferation. Question 7 You are studying a common genetic condition. The mutant allele differs from the wild-type allele by a single base-pair (bp) substitution. This substitution eliminates a NheI restriction site that is present in the wild-type allele. (The mutant allele is not cut by NheI.) A pedigree of a family exhibiting this condition is shown below: normal male affected male normal female affected female 1 2 3 4 5 6 7 8 boss/sev Ras GDP GTP transcription of genes for R7 development Ras GDP GTP EGF receptor EGF transcription of genes for cell division