C. Antihypertensive Drugs Hemodynamic Effects of Long-Term Administration of Antihypertensive Agents HEART CARDIAC TOTAL PERIPHERAL PLASMA PLASMA RENIN RATE OUTPUT RESISTANCE VOLUME ACTIVITY Diuretics Sympatholytic agents Centrally acting Adrenergic neuron blockers a-Adrenergic antagonists B-Adrenergic antagonists No iSat ISA Arteriolar vasodilators Ca T-channel blockers ↓or↑↓or↑ ACE inhibitors ATRA tISA, intrinsic sympathomimetic activity. ACE, angiotensin converting enzyme. ATRA, angiotensin Il-receplor antagonist.unchanged " Changes are indicated as follows: t, increased; 4, decreased;-t, increased or no change;-+, decreased or no change;C. Antihypertensive Drugs