二 授课内容（依据教学大纲）及时间分配 Get a general idea about neurotransmitters and associated neuropsychiatric disease 7min Get a general idea about acetylcholine and its functions and neurochemistry 8min Get a general idea about the distribution,structures and functions of cholinergic receptors 8min Get a general idea about Alzheimer disease 7min To master the chemical structures,drug design,structure-activity relationships,and mechanism of actions of major cholinergic drugs; Understand the synthesis and metabolism of major cholinergic drugs Including the following specific drugs(70 min): Muscarinic Agonists:Methacholine Chloride;Carbachol;Bethanechol Chloride;Pilocarpine;Cevimeline 20 min Acetylcholinesterase Inhibitors:Neostigmine;Rivastigmine;Tacrine; Galantamine;Donepezil; 25 min Muscarinic Antagonists:Atropine and its Analogues;Tiotropium bromide;Artane;Benztropine. 25min 三、 教学重点与难点 1.教学重点 Drug discovery and design,chemical structures,structure-activity relationships,and mechanism of actions of major cholinergic drugs二、 授课内容（依据教学大纲）及时间分配 Get a general idea about neurotransmitters and associated neuropsychiatric disease 7 min Get a general idea about acetylcholine and its functions and neurochemistry 8 min Get a general idea about the distribution, structures and functions of cholinergic receptors 8 min Get a general idea about Alzheimer disease 7 min To master the chemical structures, drug design, structure-activity relationships, and mechanism of actions of major cholinergic drugs; Understand the synthesis and metabolism of major cholinergic drugs Including the following specific drugs (70 min): Muscarinic Agonists: Methacholine Chloride; Carbachol; Bethanechol Chloride; Pilocarpine; Cevimeline 20 min Acetylcholinesterase Inhibitors: Neostigmine; Rivastigmine; Tacrine; Galantamine; Donepezil; 25 min Muscarinic Antagonists: Atropine and its Analogues; Tiotropium bromide; Artane; Benztropine. 25 min 三、 教学重点与难点 1. 教学重点 Drug discovery and design, chemical structures, structure-activity relationships, and mechanism of actions of major cholinergic drugs