同系物变换Homology principle) A(CH2)n-B彼此互为同系物 CH3 同系物的理化性质及生物活性的变化无统一规律 递变gradation 交替alternation CH3 麻醉剂 翻转inversion 100 R Duration of Anaesthesia(min) H 11 CHg 23 C2H5 34 000000010 C3Hz 49 C4Hg 93 0 HC1 C2 C3 C4 C5 C6同系物变换(Homology principle) A-(CH2 )n-B 彼此互为同系物 同系物的理化性质及生物活性的变化无统一规律 递变 gradation 交替 alternation 翻转 inversion CH3 CH3 H N CO N R 0 10 20 30 40 50 60 70 80 90 100 HC1 C2 C3 C4 C5 C6 R Duration of Anaesthesia (min) H 11 CH3 23 C2H5 34 C3H7 49 C4H9 93 麻醉剂