Ill. The pressure-natriuresis and ressure-diuresis Even with these special control mechanisms, changes in arterial pressure still have significant effects on renal excretion of water and sodium (1) The slight increase in GFR that does occur contributes in part to the effect of increased arterial pressure on urine output(P→GFR↑→Uout1) (2 )This effect result in part from a slight increase in ritubular capillary hydrostatic pressure especially in the vasa recta of the renal medulla, and a subsequent increase in the renal interstitial fluid hydrostatic pressure.(P↑→ p cap hyd p↑→ reabsorb」→ Uout t) (3)Decreased angiotensin I formation contributes to the decreased tubular sodium reabsorption that occurs when arterial pressure is increased (P↑→Ag‖↓→ eabsob↓→out)III. The pressure-natriuresis and pressure-diuresis Even with these special control mechanisms, changes in arterial pressure still have significant effects on renal excretion of water and sodium. (1) The slight increase in GFR that does occur contributes in part to the effect of increased arterial pressure on urine output. ( P↑ → GFR ↑ →Uout ↑) (3)Decreased angiotensin II formation contributes to the decreased tubular sodium reabsorption that occurs when arterial pressure is increased. (P↑ → AgII ↓ →reabsob↓ →Uout ↑) (2) This effect result in part from a slight increase in peritubular capillary hydrostatic pressure, especially in the vasa recta of the renal medulla, and a subsequent increase in the renal interstitial fluid hydrostatic pressure. (P↑ → p cap hyd p ↑ →reabsob↓ →Uout ↑)