There appear to be certain transcriptional activators (such as the glucocorticoid receptor) that can bind to existing nucleosomes and disrupt them Once the nucleosomes are dissociated in the promoter region, other transcription factors can bind Nucleosome DNA is wound around a histone core, forming Initial TF binds TF binding to to a nucleosome part of the histone core Additional factors Histone h1 may bind the Other TFs T complex, further destabilizing the histone core When the histones have been displaced, other TFs mav 1g tao eQ Histone or carrier proteinsThere appear to be certain transcriptional activators (such as the glucocorticoid receptor) that can bind to existing nucleosomes and disrupt them. Once the nucleosomes are dissociated in the promoter region, other transcription factors can bind