Review -Homology modeling Identify a protein with similar sequence for which a structure has been solved (the template) Align the target sequence with the template Use the alignment to build an approximate structure for the target Fill in any missing pieces Fine-tune the structure Evaluate success An excellent review Marti-Renom et al. Annu. Rev. Biophys. Biomol. Struct. 29 (2000): 291-325Review - Homology Modeling • Identify a protein with similar sequence for which a structure has been solved (the template) • Align the target sequence with the template • Use the alignment to build an approximate structure for the target • Fill in any missing pieces • Fine-tune the structure • Evaluate success An excellent review: Marti-Renom et al. Annu. Rev. Biophys. Biomol. Struct. 29 (2000): 291-325