Medical Genetics Affected infants have low-set ears, mid line facial clefts a small receding mandible, hypertelorism, a shortened philtrum and congenital heart disease. Tetany appears within 24 to 48 h of life, both sexes are equally affected and familial cases are uncommonMedical Genetics Affected infants have low-set ears, midline facial clefts, a small receding mandible, hypertelorism, a shortened philtrum, and congenital heart disease. Tetany appears within 24 to 48 h of life. Both sexes are equally affected, and familial cases are uncommon