Medical Genetics 2. The Symptoms of Mitochondrial Disease Loss of muscle coordination, muscle weakness Neurological problems, seizures Visual and/or hearing problems Developmental delays, learning disabilities Heart liver or kidney disease Gastrointestinal disorders severe constipation Diabetes e Increased risk of infection Thyroid and/or adrenal dysfunction Autonomic dysfunction Neuropsychological changes characterized by confusion, disorientation and memory lossMedical Genetics 2. The Symptoms of Mitochondrial Disease • Loss of muscle coordination, muscle weakness • Neurological problems, seizures • Visual and/or hearing problems • Developmental delays, learning disabilities • Heart, liver or kidney disease • Gastrointestinal disorders, severe constipation • Diabetes • Increased risk of infection • Thyroid and/or adrenal dysfunction • Autonomic dysfunction • Neuropsychological changes characterized by confusion, disorientation and memory loss