工细胞活化信号传导途径 APC 0044 CD4/CD8 CD3 Lipid raft LAT T cell 70 Adapter proteins nitiation of TCR-mediated ⊙ ⊙ sIgnals SLP-76 P PLCy GTP/GDP activation exchange on Has and Rac Biochemical intermediates Increased cytosolic Ca Diacylglycerol( DAG)RasGTP, Rac.G Distal signaling enzymes Calcineurin PKC AP kinases Transcription factors NFAT AP-1 Abbas et al: Cellular and Molecular Immunology, Updated 6th Edition.T细胞活化信号传导途径