AChE Susceptibility Muscarinic Effect hc是。-0-G-Gh-w二 CH CH Highest (++++ High Acetylcholine CH Low(+) Highest(++++) (cy) w。-otow-r< CH Negligible Medium (++ Negligible Medium(++) Cholinergic effects: Adrenergic effects: Contraction of pupillary constrictor muscle .Contraction of pupillary dilator muscle --miosis --mydriasis Contraction of ciliary muscle-bulge of lens Stimulation of ciliary epithelium --near vision,T outflow of acqueous humor --T production of aqueous humor lris、 Cornea Pathway for aqueous humour Canai of Schlemm Trabecular meshwork (opened by pilocarpine) Lens Suspensory ligaments Secretion of acqueous humor (B) Fig.6.5 The anterior chamber of the eye,showing the pathway for secretlon and drainage of the aqueous humor. 55 AChE Susceptibility Muscarinic Effect Highest (++++) High Low (+) Highest (++++) Negligible Medium (++) Negligible Medium (++) Lens Pupillary dilator muscle (α1) Pupillary constrictor muscle (M3) Secretion of acqueous humor (β) (M3) Cholinergic effects: Adrenergic effects: • Contraction of pupillary constrictor muscle -- miosis • Contraction of ciliary muscle - bulge of lens -- near vision, ↑ outflow of acqueous humor • Contraction of pupillary dilator muscle -- mydriasis • Stimulation of ciliary epithelium -- ↑ production of aqueous humor Trabecular meshwork (opened by pilocarpine)