Differentiation of cholestasis The clinical features of any form of cholestasis are similar In an affected neonate, the diagnosis of certain entities such as galactosemia, sepsis and hypothyroidism is relatively simple a In most cases the cause of cholestasis is more obscure e Differentiation among biliary atresia anepatic idopathic neonatal hepatitis, and intra cholestasis is particularly difficultDifferentiation of cholestasis ◼ The clinical features of any form of cholestasis are similar. ◼ In an affected neonate, the diagnosis of certain entities, such as galactosemia, sepsis, and hypothyroidism, is relatively simple. ◼ In most cases, the cause of cholestasis is more obscure. ◼ Differentiation among biliary atresia, idopathic neonatal hepatitis, and intrahepatic cholestasis is particularly difficult