Mechanism Associated with Exacerbation of renal function Hyperfiltration theory Effect of proteinuria Trade-off hypothesis in acidosis Disturbance of lipid metabolism Tubulointerstitial injury Renal hypoxia5 Mechanism Associated With Exacerbation of Renal Function • Hyperfiltration theory • Effect of proteinuria • Trade-off hypothesis in acidosis • Disturbance of lipid metabolism • Tubulointerstitial injury • Renal hypoxia