5HT Neuron Astrocyte Opioid Neuron Dynorphin 5HT Ca+ KOR NMDAR K 5HT 1A Adenylate Cyclase Ca ● AMPAR PKA ● CaMKII .Glu >P3 PLC PKC mGluR Afferent ● ERK Postsynaptic Neuron NMDAR Neuron ⊙< Akt Src GluR2-lacking AMPA AMPAR TrkB 00 00< TNFR1 AMPAR Trafficking ★ BDNF ●●L-1B ★TNF LPS TLR4 Microglia