Properties of herpesviruses o Enveloped double stranded dna viruses Genome consisits of long and short fragments which may be orientated in either direction, giving a total of 4 isomers ● Three subfamilies: Alphaherpesviruses-HSV-1, HSV-2, VZV Betaherpesviruses -CMV HHV-6, HHV-7 Gammaherpesviruses -EBV HHv-8 o Set up latent or persistent infection following primary infection o Reactivation are more likely to take place during periods of Immunosuppression o Both primary infection and reactivation are likely to be more serious in immunocompromised patientsProperties of herpesviruses ⚫ Enveloped double stranded DNA viruses. ⚫ Genome consisits of long and short fragments which may be orientated in either direction, giving a total of 4 isomers. ⚫ Three subfamilies: – Alphaherpesviruses - HSV-1, HSV-2, VZV – Betaherpesviruses - CMV, HHV-6, HHV-7 – Gammaherpesviruses - EBV, HHV-8 ⚫ Set up latent or persistent infection following primary infection ⚫ Reactivation are more likely to take place during periods of immunosuppression ⚫ Both primary infection and reactivation are likely to be more serious in immunocompromised patients