C iodated thyroglobulin Uptake of colloid by endocytosis (TSH, microvill)→ Lysosomes phagosomes→ 0u0 LYS→T2&T Lysosome and colloid droplet 3. Modulation of T3, T fuse secretion: hypothalamus pituitary-thyroid axis Digestion by enzymes releases 4. Function of T3, T4 thyroid hormones a elevates the basal 3,T4) metabolic rate b influence the body growth and nervous system development during fetal life Lysosomal Thyroid stimulating Cretins: Arrested mental enzyme hormone bound synthesis to receptor and physical development in adult because of 21 hypothyroid from birth21 c. iodated thyroglobulin → (TSH, microvilli) → phagosomes → LYS → T3 & T4 . 3. Modulation of T3 , T4 secretion: hypothalamus￾pituitary-thyroid axis. 4. Function of T3 , T4 : a. elevates the basal metabolic rate. b. influence the body growth and nervous system development during fetal life. Cretins: Arrested mental and physical development in adult because of hypothyroid from birth