Alterations in normal blood flow Platelets activated by contact with endothelium Slowed fow retards dilution of activated clotting factors and hepatic clearance. Stasis or turbulence retards the inflow of inhibitors Turbulence may induce endothelial iniurAlterations in normal blood flow • Platelets activated by contact with endothelium. • Slowed flow retards dilution of activated clotting factors and hepatic clearance. • Stasis or turbulence retards the inflow of inhibitors. • Turbulence may induce endothelial injury