Regulator T Cells带 Signal 2 mediated CD28 receptor plus CDgo molecule activates another tyrosine kinase formation transcription factor CD28RC, also stabilizes iL2 m-RNA increases concentration of il2 THl cells activated by 2 signals secrete large amounts of IL2 activates cytotoxic T cells BIOL 533 20 Lecture 7BIOL 533 20 Lecture 7 Regulator T Cells • Signal 2 mediated – CD28 receptor plus CD80 molecule activates another tyrosine kinase formation transcription factor CD28RC; also stabilizes IL2 m-RNA; increases concentration of IL2 – TH1 cells activated by 2 signals secrete large amounts of IL2 activates cytotoxic T cells