Treatment Principle 1. Underlying disease control 2. Reduce Ventilator induced lung injury 3. Prevention of venous thromboembolism GI bleeding, catheter infection 4. Prevent and recognition of HAP 5. Support therapy: nutrition, ventilation, fluid antibioticsTreatment Principle: 1. Underlying disease control 2. Reduce Ventilator induced lung injury 3. Prevention of venous thromboembolism, GI bleeding, catheter infection 4. Prevent and recognition of HAP 5. Support therapy: nutrition, ventilation, fluid, antibiotics