Pathogenesis Affects each tissue Accumulation of glycosaminoglycans (hyaluronic acid) t Not to excessive synthesis t But decreased destrution Increased capillary permea bility Interstitial edema t Skin ◆ Heart muscle ◆ Striated musclePathogenesis Affects each tissue Accumulation of glycosaminoglycans (hyaluronic acid)  Not to excessive synthesis  But decreased destrution Increased capillary permeability Interstitial edema  Skin  Heart muscle  Striated muscle