The half-life for the hydrolysis of a typical peptide at neutral pH is estimated to be between 10 and 1000 years. The resonance structure endows the peptide bond with partial double bond character,that accounts for the planarity of a peptide bond also makes such bonds resistant to hydrolysis.肽键共振赋予其平面结构，因此抗水解。 R H duP924h The carbonyl carbon atom is less electrophilic and less susceptible to nucleophilic attack than are the carbonyl carbon atoms in compounds such as carboxylate esters. Yet,peptide bonds must be hydrolyzed within milliseconds in some biochemical processes.The half-life for the hydrolysis of a typical peptide at neutral pH is estimated to be between 10 and 1000 years. The resonance structure endows the peptide bond with partial double bond character, that accounts for the planarity of a peptide bond also makes such bonds resistant to hydrolysis. 肽键共振赋予其平面结构，因此抗水解。 The carbonyl carbon atom is less electrophilic and less susceptible to nucleophilic attack than are the carbonyl carbon atoms in compounds such as carboxylate esters. Yet, peptide bonds must be hydrolyzed within milliseconds in some biochemical processes