Developmental Biology 生长受激素的调控 Hypothalamus Fig 14.6 Growth hormone production is under the control of the hy pothal- Growth hormone releasing hormone <7 Somatostatin amic hormones. Growth hormone is made in the pituitary gland and is secreted 计f Growth hormone- releasing hormone from the hypothalamus promotes growth hormone synthesis, while somatostatin Pituitary inhibits it. growth hormone controls its Growth hormone own release by negative feedback signals to the hypothalamus. Growth hormone causes the synthesis of the insulin-like growth factor IGF-1 and this promotes the production of growth hormone IGF-1 synthesis 缺失IGF-2基因的小鼠出生时的重量 仅为正常鼠的60%,表明IGF2是早 期胚胎生长所必需的。IGF-1主要在 出生后起作用 Cell multiplicationDevelopmental Biology 生长受激素的调控 缺失IGF-2基因的小鼠出生时的重量 仅为正常鼠的60%，表明IGF-2是早 期胚胎生长所必需的。IGF-1主要在 出生后起作用