SCENCNNEWS www.advancedsciencenews.com of the magnetoelectric microenvironment for precisely control- [7 J.J. Cook, N ). Summers, E A. Cook, Clin. Podiatr. Med. Surg. 2015 bone regeneration in situ, which holds much promise for ving efficient bone repair in the clinic. 18]C. Daish, R. Blanchard, K. Fox, P. Pivonka, E. Pirogova, Ann. Biomed. Eng. 2018, 46, 525 [9] a)H. M. Yun, S.). Ahn, K.R. Park, M.J. Kim, J.J. Kim, G. Z. in, H. W. Kim, E. C. Kim, Biomaterials 2016, 85, 88; b)S. M. Dadfar, 4. Experimental Section K. Roemhild N. I. Drude. S. von Stillfried. R. Knuchel. F Kiessling Details of the materials and experimental methods used are availabl T. Lammers, Adv. Drug Delivery Rev. 2019, 138, 302; c)C. Ning, Z. Zhou, G. Tan, Y. Zhu, C. Mao, Prog. Polym. Sci. 2018, 81, 144 no]M. Cifra, Z. Fields, A. Farhadi, Prog. Biophys. Mol. Biol. 2011, 10 P Martins, S. Lanceros-Mendez, Adv. Funct. Mater. 2013, 23, 3371 Supporting Information [2] a) V Supporting Information is available from the Wiley Online Library or M. G. Talikina, Y. V. Chebotareva, Y. G. lzyumov, A.A.Batrakova from the author V.A. Nepomnyashchikh, Biofizika 2017, 62, 675; b)V. V. Krylov, N. P. Kantserova, L. A. Lysenko, E. A. Osipova, IntJ.Bio 2019,63,241 [3]X. Zhang, C. Zhang, Y. Lin, P. Hu, Y. Shen, K. Wang, S. Meng. Acknowledgements Y. Chai, X.Dai, X Liu, Y Liu, X Mo, C. Cao, S. Li, X Deng, L Chen, ACS Nano2016,10,7279 W.L. and F.Z. contributed equally to this work. This work was [4]V. V. Krylov, Bioelectromagnetics 2017, 38, 497 by the National Key R&D Program of China(2018YFCl [5] a)M. D. Pierschbacher, E. Ruoslahti, Nature 1984 2018YFE0194400), National Natural Science Foundation b)E. Ruoslahti, Annu. Rev. Cell Dev. Biol. 1996, 12, 697 (81600905,81991505, 31670993), Peking University Medicine Fund [16]Y. Wei, S Jiang, M. Si, X. Zhang, ) Liu, Z. Wang, C. Cao, J of Fostering Young Scholars' Scientific Technological Innovation H. Huang, L Chen, S. Wang, C. Feng, X. Deng, L Jiang, Ad supported by the Fundamental Research Funds for the Central 2019,31,1900582 Foundation (182185), and Key Science and Technology Program of [7 a) M. Schwartzman, M. Palma, ). Sable, ).Abramson, X.Hu with the approval of the Animal Care and Use Committee of Peking T. Segura, Biomaterials 2013, 34, 3938 niversity(IACUC number: LA2019161) 8] T Re'em, O. Tsur-Gang, S Cohen, Biomaterials 2010, 31, 6746 9 H. Kong, S. Hsiong, D. ) Mooney, Nano Lett. 2007, 7, 161 [20] a)H. Shroff, C.G. Galbraith, ). A. Galbraith, H. White, ). Gillette S. Olenych, M. W. Davidson, E. Betzig, Proc. Natl. Acad. Sci. U.S.A Conflict of Interest 2007, 104, 20308; b)R. Changed, H. Cai, S. Wind, M. P. Sheetz, Nat.Mate:2019,18,1366 The authors declare no conflict of interest [21] a)X Ren, Y. Feng, ). Guo, H. Wang, Q. Li, J. Yang, X. Hao, ). Lv, N. Ma, W. Li, Chem. Soc. Rev. 2015, 44, 5680; b)E. M. Pierschbacher. Science 1987. 238. 491 K hae,J- U. Lee, G. H. Kim, Colloids Surf, B 2019. b)H Ta gan, E. Sadroddiny, Biomed. Pharmacother 2017, 88, 956. arginylglycylaspartic acid, bone regeneration, magnetoelectric [23)G Kocer, P. Jonkheijm, Adv. Healthcare Mater. 2017, 6, 1600862. microenvironments, nanocomposite membranes, remote tuning [24] a)Z. Hamidouche, O. Fromigue, ). Ringe, T. Haupl, P. Vaud vne. P. Received: July 23, 2020 Sci. U. S.A. 2009, 106, 18587: b)P. Chatakun, R. Nunez. Toldra Revised: September 15, 2020 Diaz Lopez, C. Gil-Recio, E. Martinez.Sarra, F. Hernandez.Alfaro, Published online E. Ferres-Padro, L Giner-Tarrida, M. Atari, Cell. Mol. Life Sci. 2014 71, 113; c)T. D. Zaveri, ) .S. Lewis, N. V Dolgova, M. ). Clare-Salzler B G. Keselowsky, Biomaterials 2014, 35, 3504. [25] P. Martins, R. Goncalves, S. Lanceros-Mendez, A. Lasheras, []S.W. Benoit, P. S. Danielle, A.R. D. Michael, K. S Anseth, Nat. 1. Gutierrez, M. Barandiaran, Appi Sci.2014,313,215 Mater.2008,7,816 [26] C. Zhang, W Liu, C. Cao, F. Zhang, Q. Tang, S. Ma, I.). Zhao, [2] a) W. Li, Z. Yan, ). Ren, X. Qu, Chem. Soc. Rev. 2018, 47, 8639: L Hu. Y. Shen, L. Chen. Adv. Healthcare Mater. 2018.7. 1701466. G. Thrivikraman, G. Madras, B. Basu, Biomaterials 2016, 77, 26. [27 a)Y. Zong, Z. Yue, P. Martins, ) Zhuang, Y Du, S. Lanceros-Mendez [3] A Maziarz, B Kocan, M. Bester, S. Budzik, M. Cholewa, T. Ochiya, M.J. Higgins, Nanoscale 2018, 10, 17370: b)B. Tang, ). Zhuang A. Banas. Stem Cell Res. Ther. 2016. 7.54 L Wang, B. Zhang, S. Lin, F Jia, L Dong, Q. Wang, K. Cheng, [4] a)P. Fomby, A.J. Cherlin, A. Hadjizadeh, C. ). Doillon, W. Weng, ACS Appl. Mater. Interfaces 2018, 10, 7841 V. Sueblinvong, D.). Weiss, ). H. T. Bates, T. Gilbert, W.C. Liles, [28 P. Martins, A. Lasheras, ). Gutierrez, M. Barandiaran, I. Orue C. Lutzko, Rajagopal, D ) Prockop, D. Chambers, A. Giangreco S. Lanceros-Mendez, Phys. D: Appl. Phys. 2011, 44, 495303 A Keating, D. Kotton, P L Lelkes, D. E. Wagner, D. ). Prockop, Ann. [29]a)H.. Chang, Y. Wang, in Regenerative Medicine and Tissue Eng Yan, Y. Ma, H Wu, C. Liu, Stem Cell Res. Ther. 2019, 1 /E.H. Li Am. Thorac. Soc. 2010, 12, 181; b)). Chen, C. Tu, X.Tan ring.Cells and Biomaterials, (Ed: D. Eberli), In Tech, London 2011 993-1001; b)). M. Rice, ) . A. Hunt, ). A. Gallagher, P. Hanarp J C. Tu, Y Xiao, Y. Ma, H. Wu, M. Song, Stem Cell Res. Ther. 2018, 9, 215. D.S.Sutherland, ). Gold, Biomaterials 2003, 24, 4799; c)).Yang, [6] a)Y Seong, ). Moon, ). Kim, Life Sci. 2014, 102, 16; b)H).Kim, Y. Zhou. F Wei Y. Xiao. Clin. Oral Im Jung, ). H. Park, ). H. Kim, K N. Ko, C. W. Kim, Exp. Biol. Med. [30] a)). Wei, T. Igarashi, N. Okumori, T. T. Maetani. B. Liu 2013.238,923 M. Yoshinari. Biomed. Mater. 2009 02; b)G. Perumal, Adw. Funct Mater. 2020. 2006226 2006226(0of1) g 2020 Wiley-VCH GmbHwww.advancedsciencenews.com www.afm-journal.de 2006226 (10 of 11) © 2020 Wiley-VCH GmbH of the magnetoelectric microenvironment for precisely control￾ling bone regeneration in situ, which holds much promise for achieving efficient bone repair in the clinic. 4. Experimental Section Details of the materials and experimental methods used are available in the Supporting Information. Supporting Information Supporting Information is available from the Wiley Online Library or from the author. Acknowledgements W.L. and F.Z. contributed equally to this work. This work was supported by the National Key R&D Program of China (2018YFC1105303/04, 2018YFE0194400), National Natural Science Foundation of China (81600905, 81991505, 31670993), Peking University Medicine Fund of Fostering Young Scholars’ Scientific & Technological Innovation supported by the Fundamental Research Funds for the Central Universities (BMU2018PY005), Beijing Municipal Natural Science Foundation (7182185), and Key Science and Technology Program of Hunan Province (2017WK2041). All animal experiments were conducted with the approval of the Animal Care and Use Committee of Peking University (IACUC number: LA2019161). Conflict of Interest The authors declare no conflict of interest. Keywords arginylglycylaspartic acid, bone regeneration, magnetoelectric microenvironments, nanocomposite membranes, remote tuning Received: July 23, 2020 Revised: September 15, 2020 Published online: [1] S. W.  Benoit, P. S.  Danielle, A. R. D.  Michael, K. S.  Anseth, Nat. Mater. 2008, 7, 816. [2] a) W.  Li, Z.  Yan, J.  Ren, X.  Qu, Chem. Soc. Rev. 2018, 47, 8639; b) G. Thrivikraman, G. Madras, B. Basu, Biomaterials 2016, 77, 26. [3] A. Maziarz, B. Kocan, M. Bester, S. Budzik, M. Cholewa, T. Ochiya, A. Banas, Stem Cell Res. Ther. 2016, 7, 54. [4] a) P.  Fomby, A. J.  Cherlin, A.  Hadjizadeh, C. J.  Doillon, V.  Sueblinvong, D. J.  Weiss, J. H. T.  Bates, T.  Gilbert, W. C.  Liles, C. Lutzko, J. Rajagopal, D. J. Prockop, D. Chambers, A. Giangreco, A. Keating, D. Kotton, P. I. Lelkes, D. E. Wagner, D. J. Prockop, Ann. Am. Thorac. Soc. 2010, 12, 181; b) J.  Chen, C.  Tu, X.  Tang, H.  Li, J. Yan, Y. Ma, H. Wu, C. Liu, Stem Cell Res. Ther. 2019, 10, 1. [5] C. Tu, Y. Xiao, Y. Ma, H. Wu, M. Song, Stem Cell Res. Ther. 2018, 9, 215. [6] a) Y.  Seong, J.  Moon, J.  Kim, Life Sci. 2014, 102, 16; b) H. J.  Kim, J. Jung, J. H. Park, J. H. Kim, K. N. Ko, C. W. Kim, Exp. Biol. Med. 2013, 238, 923. [7] J. J. Cook, N. J. Summers, E. A. Cook, Clin. Podiatr. Med. Surg. 2015, 32, 45. [8] C.  Daish, R.  Blanchard, K.  Fox, P.  Pivonka, E.  Pirogova, Ann. Biomed. Eng. 2018, 46, 525. [9] a) H. M. Yun, S. J. Ahn, K. R. Park, M. J. Kim, J. J. Kim, G. Z. Jin, H. W.  Kim, E. C.  Kim, Biomaterials 2016, 85, 88; b) S. M.  Dadfar, K. Roemhild, N. I. Drude, S. von Stillfried, R. Knüchel, F. Kiessling, T.  Lammers, Adv. Drug Delivery Rev. 2019, 138, 302; c) C.  Ning, Z. Zhou, G. Tan, Y. Zhu, C. Mao, Prog. Polym. Sci. 2018, 81, 144. [10] M. Cifra, J. Z. Fields, A. Farhadi, Prog. Biophys. Mol. Biol. 2011, 105, 223. [11] P. Martins, S. Lanceros-Méndez, Adv. Funct. Mater. 2013, 23, 3371. [12] a) V. V.  Krylov, E. A.  Osipova, N. A.  Pankova, M. G.  Talikina, Y. V.  Chebotareva, Y. G.  Izyumov, A. A.  Batrakova, V. A.  Nepomnyashchikh, Biofizika 2017, 62, 675; b) V. V.  Krylov, N. P. Kantserova, L. A. Lysenko, E. A. Osipova, Int. J. Biometeorol. 2019, 63, 241. [13] X.  Zhang, C.  Zhang, Y.  Lin, P.  Hu, Y.  Shen, K.  Wang, S.  Meng, Y. Chai, X. Dai, X. Liu, Y. Liu, X. Mo, C. Cao, S. Li, X. Deng, L. Chen, ACS Nano 2016, 10, 7279. [14] V. V. Krylov, Bioelectromagnetics 2017, 38, 497. [15] a) M. D.  Pierschbacher, E.  Ruoslahti, Nature 1984, 309, 30; b) E. Ruoslahti, Annu. Rev. Cell Dev. Biol. 1996, 12, 697. [16] Y. Wei, S. Jiang, M. Si, X. Zhang, J. Liu, Z. Wang, C. Cao, J. Huang, H. Huang, L. Chen, S. Wang, C. Feng, X. Deng, L. Jiang, Adv. Mater. 2019, 31, 1900582. [17] a) M.  Schvartzman, M.  Palma, J.  Sable, J.  Abramson, X.  Hu, M. P.  Sheetz, S. J.  Wind, Nano Lett. 2011, 11, 1306; b) J.  Lam, T. Segura, Biomaterials 2013, 34, 3938. [18] T. Re’em, O. Tsur-Gang, S. Cohen, Biomaterials 2010, 31, 6746. [19] H. J. Kong, S. Hsiong, D. J. Mooney, Nano Lett. 2007, 7, 161. [20] a) H.  Shroff, C. G.  Galbraith, J. A.  Galbraith, H.  White, J.  Gillette, S. Olenych, M. W. Davidson, E. Betzig, Proc. Natl. Acad. Sci. U. S. A. 2007, 104, 20308; b) R. Changede, H. Cai, S. J. Wind, M. P. Sheetz, Nat. Mater. 2019, 18, 1366. [21] a) X.  Ren, Y.  Feng, J.  Guo, H.  Wang, Q.  Li, J.  Yang, X.  Hao, J.  Lv, N.  Ma, W.  Li, Chem. Soc. Rev. 2015, 44, 5680; b) E.  Ruoslahti, M. Pierschbacher, Science 1987, 238, 491. [22] a) S. J.  Chae, J. U.  Lee, G. H.  Kim, Colloids Surf., B 2019, 181, 408; b) H. T. Aiyelabegan, E. Sadroddiny, Biomed. Pharmacother. 2017, 88, 956. [23] G. Koçer, P. Jonkheijm, Adv. Healthcare Mater. 2017, 6, 1600862. [24] a) Z.  Hamidouche, O.  Fromigué, J.  Ringe, T.  Häupl, P.  Vaudin, J. C.  Pagès, S.  Srouji, E.  Livne, P. J.  Marie, Proc. Natl. Acad. Sci. U. S. A. 2009, 106, 18587; b) P.  Chatakun, R.  Núñez-Toldrà, E. J. Díaz López, C. Gil-Recio, E. Martínez-Sarrà, F. Hernández-Alfaro, E. Ferrés-Padró, L. Giner-Tarrida, M. Atari, Cell. Mol. Life Sci. 2014, 71, 113; c) T. D. Zaveri, J. S. Lewis, N. V. Dolgova, M. J. Clare-Salzler, B. G. Keselowsky, Biomaterials 2014, 35, 3504. [25] P.  Martins, R.  Gonçalves, S.  Lanceros-Mendez, A.  Lasheras, J. Gutiérrez, J. M. Barandiarán, Appl. Surf. Sci. 2014, 313, 215. [26] C.  Zhang, W.  Liu, C.  Cao, F.  Zhang, Q.  Tang, S.  Ma, J. J.  Zhao, L. Hu, Y. Shen, L. Chen, Adv. Healthcare Mater. 2018, 7, 1701466. [27] a) Y. Zong, Z. Yue, P. Martins, J. Zhuang, Y. Du, S. Lanceros-Mendez, M. J.  Higgins, Nanoscale 2018, 10, 17370; b) B.  Tang, J.  Zhuang, L.  Wang, B.  Zhang, S.  Lin, F.  Jia, L.  Dong, Q.  Wang, K.  Cheng, W. Weng, ACS Appl. Mater. Interfaces 2018, 10, 7841. [28] P.  Martins, A.  Lasheras, J.  Gutierrez, J. M.  Barandiaran, I.  Orue, S. Lanceros-Mendez, J. Phys. D: Appl. Phys. 2011, 44, 495303. [29] a) H.-I.  Chang, Y.  Wang, in Regenerative Medicine and Tissue Engi￾neering - Cells and Biomaterials, (Ed: D. Eberli), InTech, London 2011, pp. 993–1001; b) J. M. Rice, J. A. Hunt, J. A. Gallagher, P. Hanarp, D. S.  Sutherland, J.  Gold, Biomaterials 2003, 24, 4799; c) J.  Yang, Y. Zhou, F. Wei, Y. Xiao, Clin. Oral Impl. Res. 2016, 27, 1031. [30] a) J.  Wei, T.  Igarashi, N.  Okumori, T.  Igarashi, T.  Maetani, B.  Liu, M.  Yoshinari, Biomed. Mater. 2009, 4, 045002; b) G.  Perumal, Adv. Funct. Mater. 2020, 2006226