Comparison of Liposomal Doxorubicin Products:Myocet Vs.DOXIL Design features ·Morphology Pharmaceutical properties -Formulation -Physical properties -Drug-loading method .Product format -Phammacy preparation In vitro drug release kinetics ·Pharmacokinetics -Plasma PK parameters -Tissue distribution pattem Conclusions OH 0 pKa2=10.161 CCH2OH OH OCH3 O OH pKa-13.20 CH3 HO NH2 pKa1=8.1512 Structure of Doxorubicin pKa1=8.15 pKa2=10.16 pKa3=13.2