alcoho 3. Alcohol: Alcohol dehydrogenase(ADH) Acetaldehyde Acetaldehyde dehydrogenase(ALDH) Acetic acid Metabolic Oxidative stress Hepatocyte injury Liver fibrosis stress (H2O 2. OH, 02") (ipid peroxidation) ↑ Extracellular Fatty liver ↓GSH matⅸ (collagen) Hepatocyte SC activation Liver sinusoidal endothelial cells-FO18 3. Alcohol：