pathophysiology a Separation in the nerve epithelium layer of retina lav y in the nerve fiber layer and in the ganglion cell main yer The exact cause of retinal separation in XLRS unclear. a The mutation of XlrS1 gene- the dysfunction of retinoschisin reduce adhesion of the retinal → retinoschisis a the dysfunction of retinoschisin- >affect muller cells- inner laver retinoschisin is lesspathophysiology ◼ Separation in the nerve epithelium layer of retina , mainly in the nerve fiber layer and in the ganglion cell layer ◼ The exact cause of retinal separation in XLRS is unclear. ◼ The mutation of XLRS1 gene→ the dysfunction of retinoschisin → reduce adhesion of the retinal →retinoschisis ◼ the dysfunction of retinoschisin→ affect muller cells→ inner layer’ retinoschisin is less