8536d_ch05_105-136 8/22/02 2: 46 PM Page 106 mac46 mac46: 1256_deh: 8536d: Goldsby et al./Immunology 5e 106 PART I1 Generation of B-Cell and T-Cell Response VISUALIZING CONCEPTS Hematopoictic stem cell None Lymphoid cel None Partial heavy-chain gene rearrangement Pro-B cell None Bone Complete heavy-chain gene rearrangement Pre-B cell u Heavy chain rogate light chain Light-chain gene rearrangement Immature b cell mIgM Change in RNA processing Mature b cell mlgM mlgD A Activated B cell x( Differentiation Periphera IgM-secretil 邮c③→米 Class switching secreting vanous Memory of various FIGURE5-1 Overview of B-cell development. The events that ripheral lymphoid organs require antigen. The labels mlgM and occur dur ng maturation in the bone marrow do not require anti- mlg D refer to membrane-associated Igs IgG, IgA, and lgE are se- gen, whereas activation and differentiation of mature B cells in pe. creted immunoglobulins logy of immunoglobulin genes to the engineering of anti- body molecules for therapeutic and research application Genetic Model Compatible Chapter II covers in detail the entire process of B-cell devel- with lg Structure opment from the first gene rearrangements in progenitor B cells to final differentiation into memory B cells and anti- The results of the immunoglobulin-sequencing studies de- body-secreting plasma cells. Figure 5-1 outlines the sequen- scribed in Chapter 4 revealed a number of features of tial stages in B-cell development, many of which result from immunoglobulin structure that were difficult to reconcile critical rearrangements with classic genetic models. Any viable model of thebiology of immunoglobulin genes to the engineering of anti￾body molecules for therapeutic and research applications. Chapter 11 covers in detail the entire process of B-cell devel￾opment from the first gene rearrangements in progenitor B cells to final differentiation into memory B cells and anti￾body-secreting plasma cells. Figure 5-1 outlines the sequen￾tial stages in B-cell development, many of which result from critical rearrangements. Genetic Model Compatible with Ig Structure The results of the immunoglobulin-sequencing studies de￾scribed in Chapter 4 revealed a number of features of immunoglobulin structure that were difficult to reconcile with classic genetic models. Any viable model of the 106 PART II Generation of B-Cell and T-Cell Responses VISUALIZING CONCEPTS FIGURE 5-1 Overview of B-cell development. The events that occur during maturation in the bone marrow do not require anti￾gen, whereas activation and differentiation of mature B cells in pe￾ripheral lymphoid organs require antigen. The labels mIgM and mIgD refer to membrane-associated Igs. IgG, IgA, and IgE are se￾creted immunoglobulins. Lymphoid cell Partial heavy-chain gene rearrangement Hematopoietic stem cell Pro-B cell Complete heavy-chain gene rearrangement Pre-B cell Light-chain gene rearrangement Immature B cell Change in RNA processing Peripheral lymphoid organs Bone marrow Mature B cell Antigen stimulation Activated B cell Differentiation IgM-secreting plasma cells Class switching Memory B cells of various isotypes Plasma cells secreting various isotypes None CELL Ig EXPRESSED None None µ Heavy chain + surrogate light chain mIgM mIgM + mIgD IgM IgG IgA IgE 8536d_ch05_105-136 8/22/02 2:46 PM Page 106 mac46 mac46:1256_des:8536d:Goldsby et al. / Immunology 5e: