Establishment of Germ Theory o De Contagione et Contagiosis Morbis(On infection and infectious diseases, 1546) o He proposed that epidemic diseases are caused by transferable tiny particles or spores"that could transmit infection by direct or indirect contact or even without contact over long distances seet tection Girolamo fracastoro symptom ourses ( italian)14781553 destroy or miasma《西佛里斯一法国疾病 expel see all Syphilis sive de morbo Gallico? dh 52Establishment of Germ Theory  De Contagione et Contagiosis Morbis(On infection and infectious diseases,1546)  He proposed that epidemic diseases are caused by transferable tiny particles or "spores" that could transmit infection by direct or indirect contact or even without contact over long distances. Girolamo Fracastoro （Italian） 1478-1553 miasma 《西佛里斯──法国疾病 （Syphilis sive de morbo Gallico）》 1521