Catabolism of Glucose:Glycolysis CH2OH Figure 22.3 HO a-Glucose The 10-step Glucose is phosphorylated by reaction with ATP to yield glucose 6-phosphate. glycolysis hohte HO pathway for OH -0H catabolizing Glucose 6-phosphate is isomerized to fructose 6-phosphate by ring opening followed by a keto-enol tautomerization. glucose to two CH.OH C=0 molecules of OH -OH pyruvate Fructose 6-phosphate is phosphorylated by reaction with ATP toyield fructose 1.6-bisphosphate C=0 HO- -H H -OH Fructose 1,6-bisphosphate undergoes ring OH opening and is cleaved by a retro-aldol reaction into glyceraldehyde 3-phosphate and dihydroxyacetone phosphate(DHAP) 3-phosphate. CH.OH H00 c=0 O POCH CHCH 5 -OH Figure 22.3 The 10-step glycolysis pathway for catabolizing glucose to two molecules of pyruvate Catabolism of Glucose: Glycolysis