binding should improve with the decrease in pH. Part of this binding will involve salt formation between the amphetamine and the albumin. Amphetamine is more likely to form salts in which it acts as the positive ion as the electrophilic nature of the albumin increases 7. Replace the ester(lactone) with a less easily hydrolysed amide group. Introduce bulky ethyl or propyl groups on either side of the lactone group to reduce the ease of hydroysis. Use an enteric 8.(a) Yes, This structure only disagrees with one rule, namely the value of logP is too high(b) No, This structure does not comply with two rules, namely: too many hydrogen bond donors and too high a molecular mass. (c)Yes. This structure only disagrees with only rule, namely the value of logP is too high 9. Drugs act by binding to their target domains. This binding is only possible if their stereoelectronic structures are complementary to those of their target domains 10. Stereoisomers can exhibit different potencies, types of activity and unwanted side effects 11. A: (a)structurally rigid groups CHNC:CH CH3 H3C O、O N(CH2CH3)2 N CH3 (b)conformations H3C-. CH3 CH3 OCOCH3 H3C-N OCOCH 3C ④CH3 H2C④ H3C N CH3 COCh OCOCH3binding should improve with the decrease in pH. Part of this binding will involve salt formation between the amphetamine and the albumin. Amphetamine is more likely to form salts in which it acts as the positive ion as the electrophilic nature of the albumin increases. 7. Replace the ester (lactone) with a less easily hydrolysed amide group. Introduce bulky ethyl or propyl groups on either side of the lactone group to reduce the ease of hydroysis. Use an enteric coating. 8. (a) Yes, This structure only disagrees with one rule, namely the value of logP is too high. (b) No, This structure does not comply with two rules, namely: too many hydrogen bond donors and too high a molecular mass. (c) Yes. This structure only disagrees with only rule, namely the value of logP is too high. 9. Drugs act by binding to their target domains. This binding is only possible if their stereoelectronic structures are complementary to those of their target domains. 10. Stereoisomers can exhibit different potencies, types of activity and unwanted side effects. 11. A: (a) structurally rigid groups CH N H C CH CH3 H3C O O H CH3 N CH3 CH3 H NH2 O N(CH2CH3 )2 O H3C O O H H N CH3 CH3 CH3 (b) conformations N H3C CH3 OCOCH3 N H3C CH3 OCOCH3 N OCOCH3 H2C N H3C H2C CH3 H3C CH3 OCOCH3 © configuration