15.2 The michael reaction OH OH Nu. RHC=C HCR RHCEC HCR+ RHC-C-CR RHC-C HCR 22)H ueno Nu(keto 1.2-addition 1, 4-addition(conjugate addition) Micheal reaction:亲核的碳负离子对亲电的共轭体系进行共轭加成 A CH2-R A一CHR A H-i-i-i-H A, A=CHO, COR COOR, AA19 15.2、The Michael reaction RHC C HCR 1) Nu-; 2) H + RHC C HCR 1 2 4 3 + RHC C H2CR 1 4 Nu 1,2-addition 1,4-addition (conjugate addition ) RHC H C 4 Nu CR 1 OH 2 O OH Nu O (enol) (keto) A CH2 R B: A CH R A' R CH A C C A' HB H C R A C C H A' A, A' = CHO, COR, COOR, NO2, CN, SO2Ph Micheal reaction: 亲核的碳负离子对亲电的共轭体系进行共轭加成