BIOMATERIALS-TISSUE INTERACTIONS BIOMATERIAL TISSUE Strength Size scale 1Onm 100nm lum 10 um 100 umImm Modulus of Elasticity Fracture mechanics I sec I day 10 days 100 days Time Scale Protein Adsorption Tissue Remodeling Particles BONE Cell-cell ear Cell interactions Metal corrosion R esponse Polymer degradation Ic on ECM proteins Release Cytokines Eicosanoids E nzymesBIOMATERIALS BIOMATERIALS -TISSUE INTERACTIONS INTERACTIONS Particles Particles BIOMATERIAL BIOMATERIAL TISSUE 10nm100nm 1µm 10 µm 100 µm 1mm 1 sec 1 day 10 days 10 days 100 days 100 days Size Scale Size Scale Time Scale Time Scale Strength Strength Modulus of Elasticity Modulus of Elasticity Fracture mechanics Fracture mechanics Protein Protein Adsorption Adsorption Cell Response Response Ion Release Release Wear Metal corrosion Metal corrosion Polymer degradation er degradation BONE Tissue Remodeling Remodeling Cell -cell interactions interactions ECM proteins ECM proteins Cytokines Cytokines Eicosanoids Eicosanoids Enzymes Enzymes