Introductory slides for Session 8 EPSTEIN-BARR VIRUS Epstein-Barr virus (EBV), is the herpesvirus that causes infectious mononucleosis and is associated with a number of cancers, particularly lymphomas in immunosuppressed persons including persons with AIDS EBV is a ubiquitous virus, so common that it has been difficult to determine whether it is the cause of certain diseases or whether it is simply there as an artifact. In Third World nations,most children are infected with EBv in most industrialized nations about 50% of the people are infected. Research has found that all of the lymphomas associated with AIDS and most lymphomas in other immunocompromised persons are connected with latent EBV infection. EBV has been found in biopsy tissue of patients with Hodgkins Courtesy of NASA. Source: "Space Flight-Induced Reactivation of Latent disease, breast cancer and some smooth muscle tumors. ebv also Epstein-Barr Virus(Epstein-Bar was formerly suspected as the cause of chro onIc f atigue Originally named chronic EBV syndrome) EBNAl is the only viral protein regularly detected in malignancies as well as in healthy virus It escapes the efficient major Histocompatibility complex(MHC) class I Diagram removed due to copyright considerations restricted cytotoxic T lymphocyte(CTL)-mediated http://www.biochemuclac.uk/bsm/protdna_/familydescriptions b3t single/1b3t single htm surveillanc EBNA1 binds to four recognition sites in the origin of latent DNA of Epstein virus and activates latent phase replication of the viralIntroductory slides for Session 8 EPSTEIN-BARR VIRUS Epstein-Barr virus (EBV), is the herpesvirus that causes infectious mononucleosis and is associated with a number of cancers, particularly lymphomas in immunosuppressed persons, including persons with AIDS. EBV is a ubiquitous virus, so common that it has been difficult to determine whether it is the cause of certain diseases or whether it is simply there as an artifact. In Third World nations, most children are infected with EBV; in most industrialized nations, about 50% of the people are infected. Research has found that all of the lymphomas associated with AIDS and most lymphomas in other immunocompromised persons are connected with latent EBV infection. EBV has been found in biopsy tissue of patients with Hodgkin's Courtesy of NASA. Source: "Space Flight-Induced Reactivation of Latent disease, breast cancer, and some smooth muscle tumors. EBV also Epstein-Barr Virus (Epstein-Barr)," was formerly suspected as the cause of chronic fatigue http://spaceresearch.nasa.gov/research_projects/ros/eb. syndrome (originally named chronic EBV syndrome). html EBNA1 is the only viral protein regularly detected in all EBV-associated malignancies as well as in healthy virus carriers. It escapes the efficient major Histocompatibility complex (MHC) class I￾restricted cytotoxic T lymphocyte (CTL)-mediated surveillance. EBNA1 binds to four recognition sites in the origin of latent DNA replication of Epstein-Barr virus and activates latent￾phase replication of the viral genomes. Diagram removed due to copyright considerations. See "Ebna1 nuclear protein" at http://www.biochem.ucl.ac.uk/bsm/prot_dna/family_descriptions/ 1b3t_single/1b3t_single.html