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R→-0oH a Ae/UR OH Magnesium Monoperoxyphthalate Formation of Epoxides by an Internal S,2 Reaction in halohydrins: Halohydrins (prepared by the addition of HoX to an alkene)undergo an internal S, 2 reaction in the presence of strong base(Naoh) to give epoxides. HOBr (NB SHH2ONDMSO) 下 Reactions of phenols Phenols, like simple alcohols, will form an anion which will undergo an S,2 reaction with alkyl halides (or alkyl groups with "good leaving groups")to give ethers. They will also react with activated carbony l compounds to undergo acyl transfer reactions; thus ary l esters are readily formed by the reaction of phenols with acid halides or acid anhydrides. As with aryl amines, the ring of phenols is electron-rich and will rapidly react with Br to give a tri-substituted productFormation of Epoxides by an Internal SN2 Reaction in Halohydrins: Halohydrins (prepared by the addition of HOX to an alkene) undergo an internal SN2 reaction in the presence of strong base (NaOH) to give epoxides. Reactions of Phenols Phenols, like simple alcohols, will form an anion which will undergo an SN2 reaction with alkyl halides (or alkyl groups with "good leaving groups") to give ethers. They will also react with activated carbonyl compounds to undergo acyl transfer reactions; thus aryl esters are readily formed by the reaction of phenols with acid halides or acid anhydrides. As with aryl amines, the ring of phenols is electron-rich and will rapidly react with Br2 to give a tri-substituted product
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