Signal transduction and Growth requlation Secreted Growth factors, e.g. EGF. PDGF Specific Receptors for Growth factors e.g., RET, EGFR Cytoplasmic Nuclear G-proteins signa proteins Transcription kinases and transduction their targets actors, e.g., proteins Growth MYC JUN. FOS 9 RAS. ABL RB Factor GenesCytoplasmic signal transduction proteins Nuclear proteins Growth Factor Genes Signal Transduction and Growth Regulation Secreted Growth factors, e.g. EGF, PDGF Specific Receptors for Growth factors e.g., RET, EGFR G-proteins and kinases, e.g., RAS, ABL, RB Transcription factors, e.g., MYC, JUN, FOS G-proteins, kinases and their targets e.g., RAS, ABL, RB