Overview of cell adhesion Cell adhesion molecules(CAM) Table 19-5 Cell Adhesion Molecule Families SOME FAMILY Ca2+ OR Mg 2+ HOMOPHILIC ORCYTOSKELETON CELL JUNCTION MEMBERS DEPENDENCE HETEROPHILIC ASSOCIATIONS ASSOCIATIONS Cell-Cell Adhesion Classical cadherins E, N, P VE homophilic actin filaments(via adherens junctions, catenins Desmosomal desmoglein, yes homophilic intermediate filaments desmosomes cadherins desmocollin (via desmoplakin, plakoglobin, and plakophilin) Ig family members N-CAM, ICAM no both unknown neuronal and immunological synapses Selectins(blood cells L,E, and heterophilic actin filaments (no prominent junctional and endothelial cells P-selectins only) Integrins on blood cells aLB2(LFA1)yes heterophilic actin filaments immunological synapses Cell-Matrix Adhesion Integrins many types ye heterophilic actin filaments(via focal adhesions talin, paxillin, filamin a-actinin, and vinculin) 4 heterophilic intermediate filaments hemidesmosomes (via plectin and dystonin) Transmembrane syndecans heterophilic actin filaments (no prominent junctional proteoglycans structure) Table 19-5 Molecular Biology of the Cell 5/e(o Garland Science 2008)Cell adhesion molecules(CAM) Overview of cell adhesion