Carvedilol or Metoprolol European Trial (COMET) 1511 patients receive 40 carvedilol (25 mg BID); 1518 receive metoprolol (50 30 mg BID) ● NYHA II-IV;EF<.35;ACE-I+ 20 ▣Car diuretic (if tolerated) 口Met Mean 58 months in trial 10 Carvedilol reduced all- cause (HR.83)and CV(.80) All cv mortality relative to meto Deaths Deaths Poole-Wilson.Lancet 2003;362:7-13Carvedilol Carvedilol or Metoprolol Metoprolol European European Trial ( Trial (COMET)  1511 patients receive carvedilol (25 mg BID); 1518 receive metoprolol (50 mg BID)  NYHA II-IV; EF<.35; ACE-I + diuretic (if tolerated)  Mean 58 months in trial  Carvedilol reduced all￾cause (HR .83) and CV (.80) mortality relative to meto 0 10 20 30 40 All CV Car Met % Poole-Wilson. Lancet 2003;362:7-13 Deaths Deaths