General Features and mechanisms o Immunologically specific ● Central tolerance generative lymphoid organs immature self-reactive lymphocyte The repertoire of mature lymphocytes cannot recognize ubiquitous or widely disseminated self antigens o Peripheral tolerance: peripheral sites mature self-reactive lymphocytes Important for maitaining unresponsiveness to self antigens that are not expressed in the generative lymphoid organsGeneral Features and Mechanisms ⚫ Immunologically specific ⚫ Central tolerance: generative lymphoid organs immature self-reactive lymphocyte ⚫ Peripheral tolerance: peripheral sites mature self-reactive lymphocytes The repertoire of mature lymphocytes cannot recognize ubiquitous or widely disseminated self antigens The repertoire of mature lymphocytes cannot recognize ubiquitous or widely disseminated self antigens Important for maitaining unresponsiveness to self antigens that are not expressed in the generative lymphoid organs