A short history Monte Carlo: N. Metropolis, A W. Rosenbluth, M.N. Rosenbluth, A.H. Teller and e. Teller, J. Chem. Phys. 21,, (1953) Molecular dynamics B.J. Alder and T.E. Wainwright, J. Chem. Phys. 27, 1208 (1957);ibid.31,459,(1959) State of the art Molecular simulation spreads more and more widely in various scientific disciplines, e. g, physics, chemistry, biology chemical engineering etc. Systems tractable nowadays: fluids with a million of particles, b1O-polymers etcA short history: Monte Carlo: N. Metropolis, A.W. Rosenbluth, M.N. Rosenbluth, A.H. Teller and E. Teller, J. Chem. Phys. 21, 1087, (1953). Molecular dynamics: B.J. Alder and T.E. Wainwright, J. Chem. Phys. 27, 1208, (1957); ibid. 31, 459, (1959). State of the art: Molecular simulation spreads more and more widely in various scientific disciplines, e.g., physics, chemistry, biology, chemical engineering etc.. Systems tractable nowadays: fluids with a million of particles, bio-polymers etc