atural polymers(e.g, collagen)used as an implant materials can undergo degradation as a result of the action of enzymes (e. g, collagenase) B. Mechanical: Mechanical loading applied by the body can lead to wear(erosion) and fatigue fracture of the device 1. Fatigue testing of implants 2. Wear due to rubbing of tissue(viz., bone) against the device8. Enzymolysis Natural polymers (e.g., collagen) used as an implant materials can undergo degradation as a result of the action of enzymes (e.g., collagenase). B. Mechanical: Mechanical loading applied by the body can lead to wear (erosion) and fatigue fracture of the device. 1. Fatigue testing of implants. 2. Wear due to rubbing of tissue (viz., bone) against the device