pyruvate CO, acetvI-CoA E2(dihydrolipoyl transacetylase consisting the core, 24 subunits hydro TPP pyruvate dehydrogenase) bound to the E core, 24 subunits (dihydrolipoyl dehydrogenase) E 3 bound to the F, core, 12 subunit (a protein kinase and phosphoprotein phosphatase, not shown here, are also part of the comple apl e (b) A model of the E. coli complex showing the three kinds of enzymes and the flexible lipoamide arms covalently attached to FA model of the E. coli pyruvate dehydrognase complex showing the three kinds of enzymes and the flexible lipoamide arms covalently attached to E2 E2 (dihydrolipoyl transacetylase): consisting the core, 24 subunits; E1 (pyruvate dehydrogenase): bound to the E2 core, 24 subunits; E3 (dihydrolipoyl dehydrogenase): bound to the E2 core, 12 subunits. (a protein kinase and phosphoprotein phosphatase, not shown here, are also part of the complex) pyruvate E2 E3 hydroxyethyl-TPP CO2 acetyl-CoA