Medical Genetics Infection of the skin and mucous membranes also is common resistant thrush may be the first sign of T-cell immunodeficiency. Oral ulcers and periodontitis also are noted particularly in granulocytic deficiencies. Conjunctivitis occurs in many antibody-deficient adults Pyoderma, severe warts, alopecia, eczema, and telangiectasia are commonMedical Genetics Infection of the skin and mucous membranes also is common. Resistant thrush may be the first sign of T-cell immunodeficiency. Oral ulcers and periodontitis also are noted, particularly in granulocytic deficiencies. Conjunctivitis occurs in many antibody-deficient adults. Pyoderma, severe warts, alopecia, eczema, and telangiectasia are common